Acetone, ACS Reagent Grade – Safety Data Sheet (SDS)

Product Name: Acetone, ACS Reagent Grade
Type: Solvent (ACS Reagent Grade)
Product Code: 10300
CAS Number: 67-64-1
Supplier: Interstate Chemical Company, Inc.
Address: 2797 Freedland Road, Hermitage, PA 16148, USA
Phone: 800-422-2436 | Fax: 724-509-1015
Email: herm-eh&s@interstatechemical.com
Website: www.interstatechemical.com
Emergency Phone: CHEMTREC 800-424-9300 (24-hour)
GHS Classification: Flammable Liquid – Category 2; STOT SE – Category 3 (Narcotic Effects)
Signal Word: Danger
NFPA Ratings: Health (2), Flammability (3), Reactivity (0)

Hazard Statements:
- H225: Highly flammable liquid and vapor.
- H336: May cause drowsiness or dizziness.
Precautionary Statements:
- Keep away from heat, sparks, open flames, and hot surfaces. No smoking.
- Keep container tightly closed and properly grounded.
- Use explosion-proof equipment and only non-sparking tools.
- Avoid breathing vapors or mist. Use outdoors or in a well-ventilated area.
- Wear protective gloves, eye, and face protection.
- Store locked up in a cool, well-ventilated area.
- Dispose of contents and container in accordance with local, state, and federal regulations.
California Prop 65: This product does not contain any substances known to the State of California to cause cancer or reproductive harm.

Inhalation: Move person to fresh air and keep at rest. Call a doctor or poison center if you feel unwell.
Skin Contact: Rinse with water and remove contaminated clothing.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and continue rinsing. Seek medical attention if irritation persists.
Ingestion: Rinse mouth and do not induce vomiting. Obtain emergency medical attention.
Note to Physicians: Treat symptomatically; monitor for respiratory depression or CNS effects.

Flash Point: –18 °C (0 °F)
Auto-Ignition Temperature: 465 °C (869 °F)
Flammable Limits: 2–12.8% (v/v)
Extinguishing Media: Dry chemical, CO₂, alcohol-resistant foam, or water spray.
Combustibility: Highly flammable; vapors may form explosive mixtures with air.
Protective Gear: Firefighters should wear self-contained breathing apparatus (SCBA).
Hazardous Decomposition: Carbon monoxide, carbon dioxide, and other organic vapors.

Use only in well-ventilated areas.
Avoid all sources of ignition and static discharge.
Do not eat, drink, or smoke while handling.
Store in a cool, fireproof location away from heat, sunlight, strong acids, and bases.
Keep containers tightly closed when not in use.

Exposure Limits (Acetone):
- ACGIH TWA: 250 ppm | STEL: 500 ppm
- OSHA PEL: 1000 ppm (2400 mg/m³)
Eyes: Chemical goggles or safety glasses.
Skin: Chemical-resistant gloves (nitrile or neoprene).
Respiratory: NIOSH-approved respirator if exposure limits are exceeded.
Clothing: Flame-retardant or antistatic protective clothing.
Ventilation: Explosion-proof ventilation or fume hood required in enclosed spaces.

Acute Oral Toxicity (Rat): LD₅₀ = 5800 mg/kg
Acute Dermal Toxicity (Rabbit): LD₅₀ = 20,000 mg/kg
Inhalation LC₅₀ (Rat): 30,000 ppm (4h)
Irritation: May cause eye and respiratory irritation.
STOT (Single Exposure): May cause drowsiness or dizziness.
Carcinogenicity: Not classified as a carcinogen by IARC, OSHA, or NTP.
Aquatic Toxicity: LC₅₀ (fish, 96h) = 5540 mg/L; EC₅₀ (Daphnia, 48h) = 12,600 mg/L.
Persistence: Readily biodegradable.
Bioaccumulation: Not expected to bioaccumulate (Log Pow = –0.24).

UN Number: 1090
Proper Shipping Name: Acetone
Hazard Class: 3 – Flammable Liquid
Packing Group: II
Marine Pollutant: No
Emergency Response Guide Number: 127
Disposal: Dispose of through an approved hazardous waste facility. Handle empty containers with care; vapors may remain flammable.